Mourinho became the third Real Madrid coach to achieve a sequence of six consecutive matches without defeat against Barcelona, following Miguel Munoz (between 1962 and 1965) and Vicente del Bosque (between 2001 and 2003), according to Opta statistics network.
Real narrowed the gap with Barcelona to three points, handing them their first defeat in the league this season, and the second consecutively across various competitions for the Catalan team after their loss to French side Paris Saint-Germain in the UEFA Champions League mid-week.
In Barcelona, Real Madrid entered the match in the absence of Brazilian winger Vinicius Junior, who was suspended after receiving a red card two weeks ago, and also missed their Belgian goalkeeper Thibaut Courtois, whose absence was announced hours before the match due to a flu symptom.
The hosts in turn missed a group of players, most notably French Jules Kounde, Eric Garcia, Dani Olmo, and Dane Andreas Christensen.
The first threat was not long in coming from Turkish Arda Guler, who fired a powerful shot inside the area that went over Barcelona's goal (5), then tried a second time with a direct shot towards the goal saved by goalkeeper Joan Garcia (18).
Brazilian Raphinha responded twice, first with a shot over the goal (22) and the second wide of it (24).
Barcelona suffered a heavy blow with the departure of fullback Xavi Espart due to an injury (30), after French Aurelien Tchouameni had tackled his foot minutes earlier, with the referee issuing only a verbal warning.
Englishman Anthony Gordon tested Russian goalkeeper Andriy Lunin, who played his first official match in a Real shirt since last May, with a shot from a difficult angle that he pushed away for a corner (38).
Mbappe was in the right place to open the scoring, albeit unintentionally, when Pedri tried to clear a cross from Ivorian Yann Diomande, but the ball struck the French striker and made its way into the net (41).
Lamine Yamal wasted an equalizer chance from close range (45), then Rodry try to compensate with a shot from the edge of the area saved by Lunin (45+1).
In the second half, Barcelona rose up and attacked the visitors' goal more, and their efforts bore fruit with a goal from Raphinha from inside the area following a pass from Pedri (61).
Güler responded with a powerful shot that García cleared (63), then Gerard Martín tried from the opposite side with a shot that Lunin brilliantly saved (66).
At a time when it seemed that Barcelona was closer to scoring the second, Mbappé did it with the second, taking advantage of the effort of his substitute compatriot Eduardo Camavinga, who broke into the penalty area and provided him with a decisive pass that put him in front of the empty goal after García came out (87).
- Bilbao overwhelms Getafe -
Athletic Bilbao overwhelmed its visitor Getafe 4-0 at San Mames stadium, continuing its unbeaten home record since falling in the opening match.
The Basque team managed to regain its balance following a draw and a defeat, thanks to goals from Alex Berenguer (17), Ghanaian Iñaki Williams (35), Aitor Paredes (70), and Yuri Berchiche (88), while Mario Martin was sent off from the visitors (86).
Bilbao raised its points tally to 12 with its third league victory this season, while Getafe's tally froze at 9 points.
Since losing its opening match against Sevilla (1-3), Bilbao has not lost at home in four consecutive matches.
This result led Getafe to suffer a sequence of six consecutive away defeats in the top division for the first time since April 2016.
Getafe has achieved only one win in its last 11 matches across all competitions, and is now only one point away from eighteenth-placed Espanyol.
Real Sociedad defeated its visitor Levante 2-1, while Celta Vigo drew goalless with Real Betis.